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Based on a few reports [68,69], the endogenous GLP-1 response to meal ingestion was for years thought to be reduced in patients with type 2 diabetes
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Unlike semaglutide oral formulations, which require fasting administration and have variable absorption tied to gastric conditions, orforglipron is a small-molecule compound that does not carry the same administration constraints, potentially broadening accessibility and adherence across diverse patient populations
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