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These medications, leveraging the effects of the insulin-regulating hormone GLP-1 via actions on peripheral and central nervous system targets, have raised hopes with their bariatric surgery-rivaling results
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Fasting insulin levels significantly decreased with tirzepatide (10 mg and 15 mg), and HOMA2-IR, a measure of insulin resistance, significantly decreased with tirzepatide (10 mg) compared to both placebo and dulaglutide
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